Scientific Expertise

• Electronic Health Records, clinical knowledge management and telemedicine systems
• Regulated information systems
• High throughput large-scale computing for systems biology data processing and knowledge generation
• Information management for sequence analysis and 2nd generation sequencing technology
• Cheminformatics, QSAR, ADMET modeling for drug discovery
• Computer-assisted molecular modeling, simulation and design (CADD)
• Statistical data modeling for biology behaviors based on systems biology

Information Technology Services

• Expert project and program management
• Data modeling and database design
• Evaluation, recommendation and independent benchmarking of computational methods and applications
• Integration of scientific computing tools, applications and databases
• Heterogeneous knowledge mining
• Automated analysis pipelines
• Validation of regulated computer systems
• Education and training in scientific computing
• Interim information systems leadership
• Assistance in international and domestic project sourcing
• Custom algorithm and application development
  • Business systems analysis
  • Functional and engineering specification
  • Multi-platform implementation
  • Continuous system testing
  • Complete documentation and support

Technology Capabilities

• Business process mapping and engineering:
  UML, Sparx Systems Enterprise Architect, Business Process Management (BPM), BPEL, Orchestra; SOA, web services
• Project management and SDLC: Rational Unified Process (RUP), Extreme Programming (XP), Scrum
• Workflow, collaboration, versioning and change control: Documentum; MS Sharepoint; MS VSS, CVS, RCS, Subversion
• Data warehousing, database development, reporting and business intelligence:
  Oracle, PL/SQL, Quest TOAD; MySQL; PostgreSQL; Versant OODBMS; Cognos; Business Objects
• Programming: J2EE, Ruby, C/C++, VBA, XML, PHP, Fortran; R, S+
• OS: UNIX (all flavors and distributions of Linux, Solaris, SGI IRIX); Windows from NT to Vista; VAX VMS
• Sequence analysis methods and software: BLAST, FASTA, Smith-Waterman, multiple alignment methods,
  HMMer, sequence assembly, Phred/Phrap/Consed, protein identification and function prediction, SignalP, Vector NTI
• Protein 3d modeling and MD simulation:
  Accelrys tools (Discovery Studio, Insight II, QUANTA, CHARMm), Xplor, Felix, MODELER, GROMOS, ChemAxon
• Cheminformatics, compound registration and computer-assisted drug design:
  Accelrys, CambridgeSoft, Molsoft, MDL ISIS, ACD software; QSPR, ADME property prediction, virtual screening;
  PK/PD: Pharsight WinNonLin
• Scientific data management, Electronic Lab Notebook (ELN), Laboratory Information Management (LIMS) software:
  Thermo Scientific LIMS (SampleManager); Waters (formerly NuGenesis) SDMS, ELN, Empower Chromatography Data
  System (CDS); CambridgeSoft ELN; SciTegic Pipeline Pilot; Agilent ChemStation, GeneSpring; Labtronics LimsLink, Collect;
  Spotfire DecisionSite
• Dynamic systems modeling for business processes, chemical reactions and metabolic pathways
• Automation and control systems: Emerson DeltaV; OSIsoft PI Historian

Dedicated Hardware

We possess an on-site 12 node production Linux cluster and hold a contract to a shared scalable parallel computing environment with over 1000 CPUs.